Biology 446 - Unsolved Problems in Cell Biology - Fall 2014

Meets Monday, Wednesday and Friday, 10:00 AM-10:50 AM, Genome Sciences Building Room 1374.

Albert Harris:
Office 103 Wilson Hall; phone 919-966-1230
Home phone 919-493-1572 (Durham)

Office Hours: 11:00 to 1:00 Monday, Wednesday and Friday; 1:30-4:00 Friday, and by appointment



Wed. August 20: Philosophy of Science Assignment: Read this web page.

Fri. August 22: Assignment: Read the book "The Double Helix" by James Watson

Mon. August 25: Continue discussing the lessons of Watson's autobiography.


Fri. August 29: Begin autoimmune diseases

Please read the following paper before the September 3rd class:

Boster et al. (2011). Efficacy, safety, and cost-effectiveness of glatiramer acetate
in the treatment of relapsing-remitting multiple sclerosis. Ther. Adv. Neurol. Disord. 4(5):319-32.

more ideas about multiple sclerosis

how to cure multiple sclerosis


Mon. September 15: Indigestible Discoveries assignment


Wednesday September 24

Gastric Ulcers and Helicobacter pylori


Dates of student presentations in Unsolved Problems:

Friday September 26Atherosclerosis
Monday September 29Clock and Wave-front theory of somite formation

Paper relevant to Monday's presentation:
Truskinovsky et al. (2014). A mechanical perspective on vertebral segmentation.
International Journal of Engineering Science 83,124-137.

You should be able to open this and download the pdf file from within the UNC system.
Please let us know if you are unable to get it.



Wednesday October 1Amyelotropic Lateral Sclerosis
Friday October 3Macrophages
Monday October 6Muscular Dystrophy
Wednesday October 8Differentiation
Friday October 10Osteoporosis
Monday October 13Malaria (and other tropical diseases?)
some questions to think about regarding some of these topics
Wednesday October 15Either Aging or Regeneration
Friday October 17Fall Vacation
engulfment in cell aggregates, and rearrangement of cells [posted October 24]

muscle cell cancers [posted October 24]

reading / discussion assignment for November 3 [posted October 31]

types of amoeboid locomotion [posted November 7]

Examples of Kuhn's Scientific Revolutions Producing New Facts, and New Questions. [posted November 16]


Two papers to read [posted November 21]:

Romereim et al. (2014) A dynamic cell adhesion surface regulates tissue architecture in growth plate cartilage.
Development 141(10):2085-2095

Fagotto (2014) The cellular basis of tissue separation.
Development 141(17):3303-3318.
[This one should be available within the UNC system; please let us know if you're unable to get it.]

Not assigned, but in case you're interested:
Harris (1976) Is cell sorting caused by differences in the work of intercellular adhesion? A critique of the Steinberg hypothesis.
J. Theor. Biol. 61(2), 267-285.


Summary of the course [posted December 3]

Final set of review questions for the final exam [posted December 6]

This is the complete set, including the two previous lists (but with a few modifications) and some additional questions.

Information about the exam format, and about grading, has been added to this file [December 8, 1:35 pm].
Please read this in preparation for the exam.



The Dreaded Erroneous (Misinterpreted) Research Paper Assignment