Syllabus  Biology 441 Vertebrate Embryology  Albert Harris    Spring 2018

MWF 9:05-9:55 Wilson 107

Office: Room 103 Wilson Hall
Office Hours: 10-12 Monday and Wednesday, or at other times by appointment

web sites: http://www. and

office phone 919-966-1230
home 919-493-1572

Teaching assistants: Lindsay Wickersham and Chris Cunningham


Lecture notes, videos, review questions, and other material needed for exams will be posted on this web site throughout the semester.
Please check it frequently for updates.

The Biology 441L lab is NOT required for students taking the lecture course. It is a separate 1-hour course.    revised lab syllabus
Labs will begin on January 24-25.

exams and grading

1) Wed. Jan 10 Mammal Embryology in Contrast with Sea Urchin Embryology
lecture notes
2) Friday Jan 12 Subdivision of Vertebrate Embryos into Ectoderm, Mesoderm & Endoderm
lecture notes
    Monday Jan 15 ******* Holiday in Honor of Martin Luther King Jr. ********
3) Wednesday Jan 17 snow day
4) Friday Jan 19 snow day
5) Monday Jan 22 Morphogenetic Movements and Shape Formation
lecture notes
6) Wednesday Jan 24 Amoeboid locomotion, Electro-osmosis and Fluid-filled Spaces
lecture notes
7) Friday Jan 26 Fish and Amphibian Embryology
drawing of early development in vertebrate embryos
lecture notes

8) Monday Jan 29 Embryology of Birds and Mammals; Extra-embryonic Membranes
lecture notes
9) Wednesday Jan 31 Regulative vs. Mosaic Development, Experimental Embryology
lecture notes
10) Friday Feb 2 Review for first examination, followed by office hours
review questions
11) Monday Feb 5 First Examination
12) Wednesday Feb 7 Some Mathematical Concepts that Are Needed to Understand Shape Formation:
Pressures, Surface Curvatures, and Tensions
lecture notes
13) Friday Feb 9 How Do Physical Forces Cause the Shapes of Anatomical Structures?
lecture notes continued from Wednesday

14) Monday Feb 12 Symmetries of Causes Control Symmetries of Anatomical Shapes
lecture notes

15) Wednesday Feb 14 Reaction-Diffusion Systems: Instabilities that Create Geometric Patterns
lecture notes

16) Friday Feb 16 Somites and Other Structures that Develop From Mesoderm
lecture notes

17) Monday Feb 19 Ovaries and Testes; Primordial Germ Cells and Gamete Formation
See the last part of the notes for Friday.
Ectoderm: lecture notes
A picture showing early neurulation was added to this page 2/25/18, 7 pm

18) Wednesday Feb 21 Retino-tectal projections: lecture notes

19) Friday Feb 23 Chemotaxis: lecture notes
Stomodeum and Endoderm: lecture notes
20) Monday Feb 26 Review for Second Examination, followed by office hours
first set of review questions
second set

21) Wednesday Feb 28 Heart Development, Guest Lecture by Chris Cunningham
The video links that were mentioned in the lecture:
classic animation used in medical school teaching
heart embryology animation using Claymation
downloadable Powerpoint file
22) Friday Mar 2 Second Examination
23) Monday Mar 5 Sponge Aggregation and Cell Sorting
lecture notes
24) Wednesday Mar 7 Lessons from the History of Cell Sorting; Beginning Limb Buds
lecture notes
25) Friday Mar 9 Limb Buds
lecture notes
 March 12-16 spring break
26) Monday Mar 19 Programmed Cell Death, and Regeneration
27) Wednesday Mar 21 to be announced
28) Friday Mar 23 to be announced
29) Monday Mar 26 to be announced
30) Wednesday Mar 28 to be announced
      Friday March 30 ******* Holiday ********
32) Monday Apr 2 Regeneration, continued
33) Wednesday Apr 4 Review for Third Examination
34) Friday Apr 6 Third Examination
35) Monday Apr 9 Metamorphosis: Tadpoles > Frogs, Caterpillars > Moths; etc.
36) Wednesday Apr 11 Immunology, Allergies and Autoimmune Diseases: How These Depend on Embryology
36) Friday Apr 13 Immunology, continued
37) Monday Apr 16 Locomotion of Amoebae and Tissue Cells
38) Wednesday Apr 18 Cell Locomotion and Traction Forces
39) Friday Apr 20 Cancer as Disruption of Embryological Mechanisms
40) Monday Apr 23 Aging
41) Wednesday Apr 25 Evolutionary Developmental Biology
42) Friday Apr 27 Review of How Development Works
  FINAL EXAM: Monday, May 7, 8:00 am